Intrathoracic nontuberculous mycobacterial infections in otherwise healthy children

Diagnosis of Nontuberculous Mycobacterial Infections

Background The nontuberculousmycobacteria (NTM) are a grouping of all Mycobacterium species other than the obligate pathogens M. tuberculosis complex and M. leprae. They are typically environmental organisms residing in soil and natural as well as treated water.1 Although generally of low pathogenicity to humans, NTM can cause a wide array of clinical diseases; pulmonary disease is most frequen...

Diagnosis of nontuberculous mycobacterial infections.

The nontuberculous mycobacteria (NTM) are typically environmental organisms residing in soil and water. Although generally of low pathogenicity to humans, NTM can cause a wide array of clinical diseases; pulmonary disease is most frequent, followed by lymphadenitis in children, skin disease by M. marinum (particularly in fish tank fanciers), and other extrapulmonary or disseminated infections i...

Extrapulmonary Nontuberculous Mycobacterial Infections in Southern Arizona

1706Characteristics of Nontuberculous Mycobacterial Infections in Thai Population

Background. Diseases caused by nontuberculous mycobacteria (NTM) have varied manifestations in different groups of patients. NTM infection has been an important cause of morbidity and mortality. We aimed to describe the clinical and microbiological characteristics, including outcomes of NTM infection in Thai population. Methods. A retrospective study was conducted among patients who were infect...

Novel STAT1 Alleles in Otherwise Healthy Patients with Mycobacterial Disease

The transcription factor signal transducer and activator of transcription-1 (STAT1) plays a key role in immunity against mycobacterial and viral infections. Here, we characterize three human STAT1 germline alleles from otherwise healthy patients with mycobacterial disease. The previously reported L706S, like the novel Q463H and E320Q alleles, are intrinsically deleterious for both interferon ga...